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Mendeley readers
Attention Score in Context
| Title |
GPCR oligomers in pharmacology and signaling
|
|---|---|
| Published in |
Molecular Brain, May 2011
|
| DOI | 10.1186/1756-6606-4-20 |
| Pubmed ID | |
| Authors |
Javier González-Maeso |
| Abstract |
G protein-coupled receptors (GPCRs) represent one of the largest families of cell surface receptors, and are the target of more than half of the current therapeutic drugs on the market. When activated by an agonist, the GPCR undergoes conformational changes that facilitate its interaction with heterotrimeric G proteins, which then relay signals to downstream intracellular effectors. Although GPCRs were thought to function as monomers, many studies support the hypothesis that G protein coupling involves the formation of GPCR homo- and/or hetero-complexes. These complex systems have been suggested to exhibit specific signaling cascades, pharmacological, internalization, and recycling properties. In this review, we summarize recent advances in our understanding of the structure, function and dynamics of GPCR complexes, as well as the findings obtained in animal models. |
Mendeley readers
The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Finland | 1 | <1% |
| Spain | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 147 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 21% |
| Researcher | 29 | 19% |
| Student > Master | 27 | 18% |
| Student > Bachelor | 20 | 13% |
| Professor > Associate Professor | 10 | 7% |
| Other | 21 | 14% |
| Unknown | 14 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 58 | 38% |
| Biochemistry, Genetics and Molecular Biology | 19 | 12% |
| Medicine and Dentistry | 17 | 11% |
| Neuroscience | 12 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 6% |
| Other | 23 | 15% |
| Unknown | 15 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2016.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Molecular Brain
#404
of 1,198 outputs
Outputs of similar age
#45,857
of 123,322 outputs
Outputs of similar age from Molecular Brain
#4
of 6 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,198 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 123,322 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.