Title |
Cyclic nucleotide specific phosphodiesterases of Leishmania major
|
---|---|
Published in |
BMC Microbiology, March 2006
|
DOI | 10.1186/1471-2180-6-25 |
Pubmed ID | |
Authors |
Andrea Johner, Stefan Kunz, Markus Linder, Yasmin Shakur, Thomas Seebeck |
Abstract |
Leishmania represent a complex of important human pathogens that belong to the systematic order of the kinetoplastida. They are transmitted between their human and mammalian hosts by different bloodsucking sandfly vectors. In their hosts, the Leishmania undergo several differentiation steps, and their coordination and optimization crucially depend on numerous interactions between the parasites and the physiological environment presented by the fly and human hosts. Little is still known about the signalling networks involved in these functions. In an attempt to better understand the role of cyclic nucleotide signalling in Leishmania differentiation and host-parasite interaction, we here present an initial study on the cyclic nucleotide-specific phosphodiesterases of Leishmania major. |
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