Title |
On the association of common and rare genetic variation influencing body mass index: a combined SNP and CNV analysis
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Published in |
BMC Genomics, May 2014
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DOI | 10.1186/1471-2164-15-368 |
Pubmed ID | |
Authors |
Roseann E Peterson, Hermine H Maes, Peng Lin, John R Kramer, Victor M Hesselbrock, Lance O Bauer, John I Nurnberger, Howard J Edenberg, Danielle M Dick, Bradley T Webb |
Abstract |
As the architecture of complex traits incorporates a widening spectrum of genetic variation, analyses integrating common and rare variation are needed. Body mass index (BMI) represents a model trait, since common variation shows robust association but accounts for a fraction of the heritability. A combined analysis of single nucleotide polymorphisms (SNP) and copy number variation (CNV) was performed using 1850 European and 498 African-Americans from the Study of Addiction: Genetics and Environment. Genetic risk sum scores (GRSS) were constructed using 32 BMI-validated SNPs and aggregate-risk methods were compared: count versus weighted and proxy versus imputation. |
Mendeley readers
Geographical breakdown
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Demographic breakdown
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