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Systems biology approach reveals that overflow metabolism of acetate in Escherichia coli is triggered by carbon catabolite repression of acetyl-CoA synthetase

Overview of attention for article published in BMC Systems Biology, December 2010
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  • Average Attention Score compared to outputs of the same age and source

Mentioned by

wikipedia
1 Wikipedia page

Citations

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187 Dimensions

Readers on

mendeley
410 Mendeley
citeulike
2 CiteULike
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Title
Systems biology approach reveals that overflow metabolism of acetate in Escherichia coli is triggered by carbon catabolite repression of acetyl-CoA synthetase
Published in
BMC Systems Biology, December 2010
DOI 10.1186/1752-0509-4-166
Pubmed ID
Authors

Kaspar Valgepea, Kaarel Adamberg, Ranno Nahku, Petri-Jaan Lahtvee, Liisa Arike, Raivo Vilu

Abstract

The biotechnology industry has extensively exploited Escherichia coli for producing recombinant proteins, biofuels etc. However, high growth rate aerobic E. coli cultivations are accompanied by acetate excretion i.e. overflow metabolism which is harmful as it inhibits growth, diverts valuable carbon from biomass formation and is detrimental for target product synthesis. Although overflow metabolism has been studied for decades, its regulation mechanisms still remain unclear.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 410 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 2%
Estonia 5 1%
Sweden 3 <1%
Netherlands 2 <1%
Germany 2 <1%
Portugal 2 <1%
Belgium 2 <1%
United Kingdom 2 <1%
New Zealand 1 <1%
Other 6 1%
Unknown 378 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 103 25%
Researcher 87 21%
Student > Master 61 15%
Student > Bachelor 30 7%
Professor > Associate Professor 15 4%
Other 56 14%
Unknown 58 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 157 38%
Biochemistry, Genetics and Molecular Biology 95 23%
Engineering 28 7%
Chemical Engineering 12 3%
Environmental Science 9 2%
Other 40 10%
Unknown 69 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2014.
All research outputs
#7,455,523
of 22,792,160 outputs
Outputs from BMC Systems Biology
#314
of 1,142 outputs
Outputs of similar age
#54,116
of 180,517 outputs
Outputs of similar age from BMC Systems Biology
#11
of 33 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,142 research outputs from this source. They receive a mean Attention Score of 3.6. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,517 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.