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Exosomal miRNAs in hepatocellular carcinoma development and clinical responses

Overview of attention for article published in Journal of Hematology & Oncology, April 2018
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Mentioned by

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2 tweeters

Readers on

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42 Mendeley
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Title
Exosomal miRNAs in hepatocellular carcinoma development and clinical responses
Published in
Journal of Hematology & Oncology, April 2018
DOI 10.1186/s13045-018-0579-3
Pubmed ID
Authors

Shuangshuang Li, Jiping Yao, Mingjie Xie, Yanning Liu, Min Zheng

Abstract

Hepatocellular carcinoma remains the sixth most lethal malignancy in the world. While HCC is often diagnosed via current biomarkers at a late stage, early detection of HCC has proven to be very difficult. Recent studies have focused on using exosomal miRNAs in clinical diagnostics and therapeutics, because they have improved stability in exosomes than as free miRNAs themselves. Exosomal miRNAs act through novel mechanisms for inducing cellular responses in a variety of biological circumstances. Dysregulated expression of miRNAs in exosomes can also accelerate HCC progression, including cell proliferation and metastasis, via alteration of a network of genes. Growing evidence demonstrates that exosomal miRNAs can affect many aspects of physiological and pathological conditions in HCC and indicates that miRNAs in exosomes can not only serve as sensitive biomarkers for cancer diagnostics and recurrence but can also potentially be used as therapeutics to target HCC progression. In this review, we summarize the latest findings between exosomal miRNAs and HCC, in order to better comprehend the functions and applications in HCC. Moreover, we discuss critical issues to consider when developing anti-tumor exosomal miRNAs as a novel therapeutic strategy for treating HCC in the clinic.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 6 14%
Student > Ph. D. Student 5 12%
Student > Master 4 10%
Researcher 4 10%
Student > Bachelor 3 7%
Other 6 14%
Unknown 14 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 24%
Medicine and Dentistry 6 14%
Immunology and Microbiology 3 7%
Engineering 2 5%
Agricultural and Biological Sciences 2 5%
Other 3 7%
Unknown 16 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2018.
All research outputs
#8,049,078
of 12,830,933 outputs
Outputs from Journal of Hematology & Oncology
#316
of 565 outputs
Outputs of similar age
#163,139
of 271,602 outputs
Outputs of similar age from Journal of Hematology & Oncology
#1
of 1 outputs
Altmetric has tracked 12,830,933 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 565 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,602 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them