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Demographic determinants of syphilis seroprevalence among U.S. blood donors, 2011–2012

Overview of attention for article published in BMC Infectious Diseases, February 2015
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Title
Demographic determinants of syphilis seroprevalence among U.S. blood donors, 2011–2012
Published in
BMC Infectious Diseases, February 2015
DOI 10.1186/s12879-015-0805-3
Pubmed ID
Authors

Mark Andrew Kane, Evan Martin Bloch, Roberta Bruhn, Zhanna Kaidarova, Edward Laurence Murphy

Abstract

No cases of transfusion-transmitted syphilis have been described for over four decades. While there is mandatory transfusion screening for syphilis, the absence of transmission is in part ascribed to a low prevalence of syphilis in the blood donor population, the concomitant use of antibiotics in a high proportion of transfusion recipients, allied with poor survival of T. pallidum during refrigerated storage of blood products. A cross-sectional retrospective data analysis was conducted to ascertain the prevalence of Treponema pallidum antibodies in U.S. blood donors by demography and geography. Routine blood donation testing data and demographics were extracted from the data warehouse of a large network of U.S. blood centers. Crude and adjusted prevalence of T. pallidum antibodies and active syphilis infection were calculated, and GIS mapping was used to illustrate geographic distribution. The prevalence of T. pallidum seropositivity and active syphilis in first time donors was 162.6 (95% CI 145.5-181.2) per 100,000 donors and 15.8 (95% CI 10.8-22.3) per 100,000 donors, respectively. The odds of T. pallidum seropositivity were significantly elevated in African American (OR = 18.9, 95% CI 14.2-25.2), and Hispanic (OR = 2.8, 95% CI 2.0-3.8) as compared to Caucasian donors. Similarly, the odds of active T. pallidum infections were significantly higher in African American (OR 15.0, 95% CI 7.0-32.3) and Hispanic (OR = 5.8, 95% CI 2.9-11.6) as compared to Caucasian donors. Syphilis seropositivity was associated with first time blood donation, increasing age, lower education, birth outside the US, and positive tests for HIV and HCV. Geographically, T. pallidum seropositivity was increased in southern and western regions of the US. Given the low seroprevalence of syphilis in blood donors, continued screening remains debatable; however it may provide a public health benefit through surveillance of at-risk populations.

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The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Unknown 62 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 17%
Student > Master 8 13%
Student > Postgraduate 5 8%
Other 4 6%
Researcher 4 6%
Other 10 16%
Unknown 21 33%
Readers by discipline Count As %
Medicine and Dentistry 13 21%
Nursing and Health Professions 9 14%
Social Sciences 3 5%
Agricultural and Biological Sciences 3 5%
Immunology and Microbiology 2 3%
Other 8 13%
Unknown 25 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2015.
All research outputs
#18,401,176
of 22,792,160 outputs
Outputs from BMC Infectious Diseases
#5,597
of 7,674 outputs
Outputs of similar age
#281,324
of 385,323 outputs
Outputs of similar age from BMC Infectious Diseases
#108
of 154 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,674 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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We're also able to compare this research output to 154 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.