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Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials

Overview of attention for article published in BMC Complementary Medicine and Therapies, February 2018
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  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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7 X users

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Title
Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials
Published in
BMC Complementary Medicine and Therapies, February 2018
DOI 10.1186/s12906-018-2130-z
Pubmed ID
Authors

Yan Sun, Xia Xu, Jinping Zhang, Yuanyuan Chen

Abstract

Depression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depression empirically. We present a systematic review and meta-analysis of the therapeutic efficacy and safety of Chai Hu Shu Gan San in treating depression. Several databases, including PubMed, China National Knowledge Internet, Wanfang, Chongqing VIP, and the Cochrane library, were systematically searched from their date of foundation to January 1, 2017. In this review, wehave included randomized control trials that compared Chai Hu Shu Gan San (or its combination with a regular Western medicine) with a regular Western medicine alone for the treatment of depression. Two investigators independently extracted and analyzed the data using RevMan 5.2.0 software. Mean difference (with a 95% confidence interval) was used as efficacy indices for outcomes. We included 42 studies involving 3234 patients with depression in 15 different types of diseases. Meta analyses showed better effect of Chai Hu Shu Gan San than fluoxetine for pure depression (MD = - 1.59, from - 2.82 to - 0.37, 4 trials, I2 = 26%), for post-stroke depression (MD = - 4.20, from - 6.20 to - 2.19, 7 trials, I2 = 96%), and for postpartum depression (MD = - 4.10, from - 7.48 to - 0.72 7 trials, I2 = 86%). None of the articles reported severe adverse events of oral administration of Chai Hu Shu Gan San. Furthermore, any adverse effects of using Chai Hu Shu Gan San alone were fewer than those of regular Western medicines. This review found that Chai Hu Shu Gan San has some advantages in treating depression, especially post-stroke depression and post-partum depression. A meticulously designed and conducted randomized control trial is needed for further evaluation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 99 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 19 19%
Student > Master 14 14%
Researcher 6 6%
Student > Ph. D. Student 6 6%
Student > Doctoral Student 6 6%
Other 18 18%
Unknown 30 30%
Readers by discipline Count As %
Medicine and Dentistry 22 22%
Nursing and Health Professions 15 15%
Psychology 13 13%
Biochemistry, Genetics and Molecular Biology 4 4%
Neuroscience 4 4%
Other 10 10%
Unknown 31 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2020.
All research outputs
#7,395,745
of 23,281,392 outputs
Outputs from BMC Complementary Medicine and Therapies
#1,200
of 3,680 outputs
Outputs of similar age
#128,379
of 331,442 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#43
of 116 outputs
Altmetric has tracked 23,281,392 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 3,680 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,442 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.