Title |
An ultrasensitive sorting mechanism for EGF Receptor Endocytosis
|
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Published in |
BMC Systems Biology, April 2008
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DOI | 10.1186/1752-0509-2-32 |
Pubmed ID | |
Authors |
Hannah Schmidt-Glenewinkel, Ivayla Vacheva, Daniela Hoeller, Ivan Dikic, Roland Eils |
Abstract |
The Epidermal Growth Factor (EGF) receptor has been shown to internalize via clathrin-independent endocytosis (CIE) in a ligand concentration dependent manner. From a modeling point of view, this resembles an ultrasensitive response, which is the ability of signaling networks to suppress a response for low input values and to increase to a pre-defined level for inputs exceeding a certain threshold. Several mechanisms to generate this behaviour have been described theoretically, the underlying assumptions of which, however, have not been experimentally demonstrated for the EGF receptor internalization network. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 4 | 14% |
India | 1 | 3% |
Unknown | 24 | 83% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 38% |
Researcher | 5 | 17% |
Professor | 3 | 10% |
Student > Bachelor | 2 | 7% |
Student > Master | 2 | 7% |
Other | 3 | 10% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 52% |
Medicine and Dentistry | 3 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Nursing and Health Professions | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 5 | 17% |
Unknown | 2 | 7% |