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An ultrasensitive sorting mechanism for EGF Receptor Endocytosis

Overview of attention for article published in BMC Systems Biology, April 2008
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Citations

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Title
An ultrasensitive sorting mechanism for EGF Receptor Endocytosis
Published in
BMC Systems Biology, April 2008
DOI 10.1186/1752-0509-2-32
Pubmed ID
Authors

Hannah Schmidt-Glenewinkel, Ivayla Vacheva, Daniela Hoeller, Ivan Dikic, Roland Eils

Abstract

The Epidermal Growth Factor (EGF) receptor has been shown to internalize via clathrin-independent endocytosis (CIE) in a ligand concentration dependent manner. From a modeling point of view, this resembles an ultrasensitive response, which is the ability of signaling networks to suppress a response for low input values and to increase to a pre-defined level for inputs exceeding a certain threshold. Several mechanisms to generate this behaviour have been described theoretically, the underlying assumptions of which, however, have not been experimentally demonstrated for the EGF receptor internalization network.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 4 14%
India 1 3%
Unknown 24 83%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 38%
Researcher 5 17%
Professor 3 10%
Student > Bachelor 2 7%
Student > Master 2 7%
Other 3 10%
Unknown 3 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 52%
Medicine and Dentistry 3 10%
Biochemistry, Genetics and Molecular Biology 2 7%
Nursing and Health Professions 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 5 17%
Unknown 2 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2011.
All research outputs
#7,455,523
of 22,792,160 outputs
Outputs from BMC Systems Biology
#314
of 1,142 outputs
Outputs of similar age
#28,481
of 81,969 outputs
Outputs of similar age from BMC Systems Biology
#2
of 7 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,142 research outputs from this source. They receive a mean Attention Score of 3.6. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 81,969 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.