Title |
Mechanisms involved in breast cancer liver metastasis
|
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Published in |
Journal of Translational Medicine, February 2015
|
DOI | 10.1186/s12967-015-0425-0 |
Pubmed ID | |
Authors |
Rui Ma, Yili Feng, Shuang Lin, Jiang Chen, Hui Lin, Xiao Liang, Heming Zheng, Xiujun Cai |
Abstract |
Liver metastasis is a frequent occurrence in patients with breast cancer; however, the available treatments are limited and ineffective. While liver-specific homing of breast cancer cells is an important feature of metastasis, the formation of liver metastases is not random. Indeed, breast cancer cell factors contribute to the liver microenvironment. Major breakthroughs have been achieved recently in understanding breast cancer liver metastasis (BCLM). The process of liver metastasis consists of multiple steps and involves various factors from breast cancer cells and the liver microenvironment. A further understanding of the roles of breast cancer cells and the liver microenvironment is crucial to guide future work in clinical treatments. In this review we discuss the contribution of breast cancer cells and the liver microenvironment to liver metastasis, with the aim to improve therapeutic efficacy for patients with BCLM. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
United States | 1 | <1% |
Unknown | 183 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 29 | 16% |
Student > Bachelor | 29 | 16% |
Student > Master | 25 | 14% |
Researcher | 20 | 11% |
Student > Doctoral Student | 9 | 5% |
Other | 16 | 9% |
Unknown | 57 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 43 | 23% |
Biochemistry, Genetics and Molecular Biology | 33 | 18% |
Agricultural and Biological Sciences | 20 | 11% |
Engineering | 6 | 3% |
Chemistry | 6 | 3% |
Other | 21 | 11% |
Unknown | 56 | 30% |