Title |
Pseudogenes transcribed in breast invasive carcinoma show subtype-specific expression and ceRNA potential
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Published in |
BMC Genomics, February 2015
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DOI | 10.1186/s12864-015-1227-8 |
Pubmed ID | |
Authors |
Joshua D Welch, Jeanette Baran-Gale, Charles M Perou, Praveen Sethupathy, Jan F Prins |
Abstract |
Recent studies have shown that some pseudogenes are transcribed and contribute to cancer when dysregulated. In particular, pseudogene transcripts can function as competing endogenous RNAs (ceRNAs). The high similarity of gene and pseudogene nucleotide sequence has hindered experimental investigation of these mechanisms using RNA-seq. Furthermore, previous studies of pseudogenes in breast cancer have not integrated miRNA expression data in order to perform large-scale analysis of ceRNA potential. Thus, knowledge of both pseudogene ceRNA function and the role of pseudogene expression in cancer are restricted to isolated examples. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 43% |
United Kingdom | 1 | 14% |
France | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
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Scientists | 4 | 57% |
Members of the public | 3 | 43% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 1% |
Italy | 1 | 1% |
Sweden | 1 | 1% |
United Kingdom | 1 | 1% |
New Zealand | 1 | 1% |
Mexico | 1 | 1% |
Japan | 1 | 1% |
Unknown | 71 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 21% |
Student > Master | 14 | 18% |
Student > Ph. D. Student | 13 | 17% |
Student > Bachelor | 7 | 9% |
Student > Doctoral Student | 6 | 8% |
Other | 13 | 17% |
Unknown | 9 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 22 | 28% |
Agricultural and Biological Sciences | 21 | 27% |
Medicine and Dentistry | 12 | 15% |
Computer Science | 7 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Other | 3 | 4% |
Unknown | 12 | 15% |