Title |
Increased expression of colony stimulating factor-1 is a predictor of poor prognosis in patients with clear-cell renal cell carcinoma
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Published in |
BMC Cancer, February 2015
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DOI | 10.1186/s12885-015-1076-5 |
Pubmed ID | |
Authors |
Liu Yang, Qian Wu, Le Xu, Weijuan Zhang, Yu Zhu, Haiou Liu, Jiejie Xu, Jianxin Gu |
Abstract |
This study aims to evaluate the impact of colony stimulating factor-1 (CSF-1) expression on recurrence and survival of patients with clear-cell renal cell carcinoma (ccRCC) following surgery. We retrospectively enrolled 267 patients (195 in the training cohort and 72 in the validation cohort) with ccRCC undergoing nephrectomy at a single institution. Clinicopathologic features, cancer-specific survival (CSS) and recurrence-free survival (RFS) were recorded. CSF-1 levels were assessed by immunohistochemistry in tumor tissues. Kaplan-Meier method was applied to compare survival curves. Cox regression models were used to analyze the impact of prognostic factors on CSS and RFS. Concordance index (C-index) was calculated to assess predictive accuracy. In both cohorts, CSF-1 expression positively correlated with advanced Fuhrman grade and necrosis. High CSF-1 expression indicated poor survival and early recurrence of ccRCC patients after surgery, especially those with advanced TNM stage disease. Multivariate Cox regression analysis showed CSF-1 expression was an independent unfavorable prognostic factor for recurrence and survival. The predictive accuracy of the University of California Los Angeles Integrated Staging System (UISS) was significantly improved when CSF-1 expression was incorporated. High CSF-1 expression is a potential adverse prognostic biomarker for recurrence and survival of ccRCC patients after nephrectomy. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 22 | 100% |
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Researcher | 5 | 23% |
Student > Bachelor | 4 | 18% |
Student > Ph. D. Student | 3 | 14% |
Professor | 2 | 9% |
Student > Doctoral Student | 2 | 9% |
Other | 1 | 5% |
Unknown | 5 | 23% |
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Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Immunology and Microbiology | 2 | 9% |
Nursing and Health Professions | 1 | 5% |
Other | 1 | 5% |
Unknown | 7 | 32% |