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A genome-wide association study of immune response traits in Canadian Holstein cattle

Overview of attention for article published in BMC Genomics, July 2014
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Title
A genome-wide association study of immune response traits in Canadian Holstein cattle
Published in
BMC Genomics, July 2014
DOI 10.1186/1471-2164-15-559
Pubmed ID
Authors

Kathleen A Thompson-Crispi, Mehdi Sargolzaei, Ricardo Ventura, Mohammed Abo-Ismail, Filippo Miglior, Flavio Schenkel, Bonnie A Mallard

Abstract

Breeding for enhanced immune response (IR) has been suggested as a tool to improve inherent animal health. Dairy cows with superior antibody-mediated (AMIR) and cell-mediated immune responses (CMIR) have been demonstrated to have a lower occurrence of many diseases including mastitis. Adaptive immune response traits are heritable, and it is, therefore, possible to breed for improved IR, decreasing the occurrence of disease. The objective of this study was to perform genome-wide association studies to determine differences in genetic profiles among Holstein cows classified as High or Low for AMIR and CMIR. From a total of 680 cows with immune response phenotypes, 163 cows for AMIR (81 High and 82 Low) and 140 for CMIR (75 High and 65 Low) were selectively genotyped using the Illumina Bovine SNP50 BeadChip. Results were validated using an unrelated population of 164 Holstein bulls IR phenotyped for AMIR and 146 for CMIR.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 <1%
United States 1 <1%
Unknown 118 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 24%
Researcher 24 20%
Student > Master 24 20%
Student > Doctoral Student 6 5%
Student > Bachelor 4 3%
Other 9 8%
Unknown 24 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 47 39%
Biochemistry, Genetics and Molecular Biology 19 16%
Veterinary Science and Veterinary Medicine 10 8%
Medicine and Dentistry 6 5%
Immunology and Microbiology 3 3%
Other 5 4%
Unknown 30 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2015.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from BMC Genomics
#9,840
of 11,244 outputs
Outputs of similar age
#208,287
of 242,216 outputs
Outputs of similar age from BMC Genomics
#222
of 263 outputs
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So far Altmetric has tracked 11,244 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 263 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.