Title |
A genome-wide association study of immune response traits in Canadian Holstein cattle
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Published in |
BMC Genomics, July 2014
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DOI | 10.1186/1471-2164-15-559 |
Pubmed ID | |
Authors |
Kathleen A Thompson-Crispi, Mehdi Sargolzaei, Ricardo Ventura, Mohammed Abo-Ismail, Filippo Miglior, Flavio Schenkel, Bonnie A Mallard |
Abstract |
Breeding for enhanced immune response (IR) has been suggested as a tool to improve inherent animal health. Dairy cows with superior antibody-mediated (AMIR) and cell-mediated immune responses (CMIR) have been demonstrated to have a lower occurrence of many diseases including mastitis. Adaptive immune response traits are heritable, and it is, therefore, possible to breed for improved IR, decreasing the occurrence of disease. The objective of this study was to perform genome-wide association studies to determine differences in genetic profiles among Holstein cows classified as High or Low for AMIR and CMIR. From a total of 680 cows with immune response phenotypes, 163 cows for AMIR (81 High and 82 Low) and 140 for CMIR (75 High and 65 Low) were selectively genotyped using the Illumina Bovine SNP50 BeadChip. Results were validated using an unrelated population of 164 Holstein bulls IR phenotyped for AMIR and 146 for CMIR. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | <1% |
United States | 1 | <1% |
Unknown | 118 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 29 | 24% |
Researcher | 24 | 20% |
Student > Master | 24 | 20% |
Student > Doctoral Student | 6 | 5% |
Student > Bachelor | 4 | 3% |
Other | 9 | 8% |
Unknown | 24 | 20% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 47 | 39% |
Biochemistry, Genetics and Molecular Biology | 19 | 16% |
Veterinary Science and Veterinary Medicine | 10 | 8% |
Medicine and Dentistry | 6 | 5% |
Immunology and Microbiology | 3 | 3% |
Other | 5 | 4% |
Unknown | 30 | 25% |