Title |
Role of microRNA in chronic lymphocytic leukemia onset and progression
|
---|---|
Published in |
Journal of Hematology & Oncology, February 2015
|
DOI | 10.1186/s13045-015-0112-x |
Pubmed ID | |
Authors |
Veronica Balatti, Yuri Pekarky, Carlo M Croce |
Abstract |
B-cell chronic lymphocytic leukemia (CLL) is the most common human leukemia occurring as indolent or aggressive form. CLL clinical features and genetic abnormalities are well documented, but molecular details are still under investigation. MicroRNAs are small non-coding RNAs involved in several cellular processes and expressed in a tissue-specific manner. MicroRNAs regulate gene expression, and their deregulation can alter expression levels of genes involved in development/progression of tumors. In CLL, microRNAs can function as oncogenes or tumor suppressors and can also serve as markers for CLL onset/progression. Here, we discuss the most recent findings about the role of microRNAs in CLL and how this knowledge can be used to identify new biomarkers and treatment approaches. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
United Kingdom | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 2 | 2% |
Portugal | 1 | <1% |
Uruguay | 1 | <1% |
South Africa | 1 | <1% |
Unknown | 96 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 21 | 21% |
Student > Ph. D. Student | 17 | 17% |
Student > Bachelor | 15 | 15% |
Researcher | 9 | 9% |
Professor > Associate Professor | 6 | 6% |
Other | 16 | 16% |
Unknown | 17 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 31 | 31% |
Agricultural and Biological Sciences | 17 | 17% |
Medicine and Dentistry | 16 | 16% |
Chemistry | 4 | 4% |
Immunology and Microbiology | 3 | 3% |
Other | 10 | 10% |
Unknown | 20 | 20% |