Title |
Further evidence for an anti-inflammatory role of artesunate in experimental cerebral malaria
|
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Published in |
Malaria Journal, November 2013
|
DOI | 10.1186/1475-2875-12-388 |
Pubmed ID | |
Authors |
Aline S Miranda, Fátima Brant, Natália P Rocha, Daniel Cisalpino, David H Rodrigues, Danielle G Souza, Fabiana S Machado, Milene A Rachid, Antônio L Teixeira Jr, Alline C Campos |
Abstract |
Cerebral malaria (CM) is a clinical syndrome resulting from Plasmodium falciparum infection. A wide range of clinical manifestations follow the disease including cognitive dysfunction, seizures and coma. CM pathogenesis remains incompletely understood and without treatment this condition is invariably fatal. Artesunate has been accepted as the most effective drug for treating severe malaria. Besides its antiparasitic activity, an anti-inflammatory property has also been reported. In the current study, the immunomodulatory role of artesunate was investigated using a Plasmodium berghei ANKA model of CM, trough evaluation of behavioural changes and cytokines expression in hippocampus and in frontal cortex. |
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Mendeley readers
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