Title |
Investigating the utility of clinical outcome-guided mutual information network in network-based Cox regression
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Published in |
BMC Systems Biology, January 2015
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DOI | 10.1186/1752-0509-9-s1-s8 |
Pubmed ID | |
Authors |
Hyun-hwan Jeong, So Yeon Kim, Kyubum Wee, Kyung-Ah Sohn |
Abstract |
Network-based approaches have recently gained considerable popularity in high- dimensional regression settings. For example, the Cox regression model is widely used in expression analysis to predict the survival of patients. However, as the number of genes becomes substantially larger than the number of samples, the traditional Cox or L2-regularized Cox models are still prone to noise and produce unreliable estimations of regression coefficients. A recent approach called the network-based Cox (Net-Cox) model attempts to resolve this issue by incorporating prior gene network information into the Cox regression. The Net-Cox model has shown to outperform the models that do not use this network information. |
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United States | 2 | 50% |
Saudi Arabia | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
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Scientists | 3 | 75% |
Members of the public | 1 | 25% |
Mendeley readers
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Unknown | 13 | 93% |
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Researcher | 3 | 21% |
Other | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Student > Bachelor | 1 | 7% |
Other | 3 | 21% |
Unknown | 1 | 7% |
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Other | 4 | 29% |
Unknown | 1 | 7% |