Title |
Integrating multiple networks for protein function prediction
|
---|---|
Published in |
BMC Systems Biology, January 2015
|
DOI | 10.1186/1752-0509-9-s1-s3 |
Pubmed ID | |
Authors |
Guoxian Yu, Hailong Zhu, Carlotta Domeniconi, Maozu Guo |
Abstract |
High throughput techniques produce multiple functional association networks. Integrating these networks can enhance the accuracy of protein function prediction. Many algorithms have been introduced to generate a composite network, which is obtained as a weighted sum of individual networks. The weight assigned to an individual network reflects its benefit towards the protein functional annotation inference. A classifier is then trained on the composite network for predicting protein functions. However, since these techniques model the optimization of the composite network and the prediction tasks as separate objectives, the resulting composite network is not necessarily optimal for the follow-up protein function prediction. |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 30 | 100% |
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Student > Master | 7 | 23% |
Student > Bachelor | 4 | 13% |
Researcher | 4 | 13% |
Student > Ph. D. Student | 3 | 10% |
Professor > Associate Professor | 2 | 7% |
Other | 3 | 10% |
Unknown | 7 | 23% |
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Unspecified | 1 | 3% |
Sports and Recreations | 1 | 3% |
Other | 0 | 0% |
Unknown | 7 | 23% |