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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs
|
|---|---|
| Published in |
Retrovirology, August 2014
|
| DOI | 10.1186/s12977-014-0070-3 |
| Pubmed ID | |
| Authors |
Pawel Bonczkowski, Ward De Spiegelaere, Alberto Bosque, Cory H White, Anouk Van Nuffel, Eva Malatinkova, Maja Kiselinova, Wim Trypsteen, Wojciech Witkowski, Jolien Vermeire, Bruno Verhasselt, Laura Martins, Christopher H Woelk, Vicente Planelles, Linos Vandekerckhove |
| Abstract |
The central memory T cell (TCM) model forms a unique HIV-1 latency model based on primary cells that closely resemble in vivo TCM. The virus employed in this model is based on an engineered vector incapable of replication after initial infection. We show that despite this strategy, replication competent viral particles are released into the culture medium due to recombination between overlapping sequences of the env deleted HIV genome that is co-transfected with intact env. This finding emphasizes the need for careful data analysis and interpretation if similar constructs are employed and urges for additional caution during laboratory work. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 3% |
| Unknown | 33 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 29% |
| Student > Master | 5 | 15% |
| Other | 4 | 12% |
| Student > Bachelor | 4 | 12% |
| Student > Ph. D. Student | 4 | 12% |
| Other | 2 | 6% |
| Unknown | 5 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 21% |
| Medicine and Dentistry | 6 | 18% |
| Immunology and Microbiology | 6 | 18% |
| Biochemistry, Genetics and Molecular Biology | 5 | 15% |
| Nursing and Health Professions | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 7 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2022.
All research outputs
#15,679,186
of 23,299,593 outputs
Outputs from Retrovirology
#785
of 1,112 outputs
Outputs of similar age
#137,974
of 237,152 outputs
Outputs of similar age from Retrovirology
#9
of 11 outputs
Altmetric has tracked 23,299,593 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,112 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,152 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.