Title |
Inherent transcriptional signatures of NK cells are associated with response to IFNα + rivabirin therapy in patients with Hepatitis C Virus
|
---|---|
Published in |
Journal of Translational Medicine, January 2015
|
DOI | 10.1186/s12967-015-0428-x |
Pubmed ID | |
Authors |
Maria Ascierto, Federica Bozzano, Davide Bedognetti, Francesco Marras, Cathy Schechterly, Kentaro Matsuura, Antonino Picciotto, Simona Marenco, Yingdong Zhao, Valeria DeGiorgi, Michele Sommariva, Lorenzo Moretta, Ena Wang, Harvey J Alter, Francesco M Marincola, Andrea De Maria |
Abstract |
Differences in the expression of Natural Killer cell receptors have been reported to reflect divergent clinical courses in patients with chronic infections or tumors. However, extensive molecular characterization at the transcriptional level to support this view is lacking. The aim of this work was to characterize baseline differences in purified NK cell transcriptional activity stratified by response to treatment with PEG-IFNα/RBV in patients chronically infected with HCV. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 5% |
Unknown | 20 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 33% |
Student > Ph. D. Student | 4 | 19% |
Student > Master | 2 | 10% |
Other | 1 | 5% |
Student > Doctoral Student | 1 | 5% |
Other | 2 | 10% |
Unknown | 4 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 33% |
Agricultural and Biological Sciences | 5 | 24% |
Immunology and Microbiology | 1 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Social Sciences | 1 | 5% |
Other | 1 | 5% |
Unknown | 5 | 24% |