Title |
Randomized controlled phase I/II study to investigate immune stimulatory effects by low dose radiotherapy in primarily operable pancreatic cancer
|
---|---|
Published in |
BMC Cancer, April 2011
|
DOI | 10.1186/1471-2407-11-134 |
Pubmed ID | |
Authors |
Carmen Timke, Hubertus Schmitz Winnenthal, Felix Klug, Falk FF Roeder, Andreas Bonertz, Christoph Reissfelder, Nathalie Rochet, Moritz Koch, Christine Tjaden, Markus W Buechler, Juergen Debus, Jens Werner, Philipp Beckhove, Jürgen Weitz, Peter E Huber |
Abstract |
The efficiencies of T cell based immunotherapies are affected by insufficient migration and activation of tumor specific effector T cells in the tumor. Accumulating evidence exists on the ability of ionizing radiation to modify the tumor microenvironment and generate inflammation. The aim of this phase I/II clinical trial is to evaluate whether low dose single fraction radiotherapy can improve T cell associated antitumor immune response in patients with pancreatic cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 1% |
Unknown | 78 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 23% |
Unspecified | 10 | 13% |
Student > Master | 9 | 11% |
Student > Ph. D. Student | 8 | 10% |
Student > Doctoral Student | 5 | 6% |
Other | 13 | 16% |
Unknown | 16 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 30% |
Unspecified | 10 | 13% |
Agricultural and Biological Sciences | 9 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Psychology | 3 | 4% |
Other | 8 | 10% |
Unknown | 20 | 25% |