Title |
The role of mitochondrial function in gold nanoparticle mediated radiosensitisation
|
---|---|
Published in |
Cancer Nanotechnology, September 2014
|
DOI | 10.1186/s12645-014-0005-7 |
Pubmed ID | |
Authors |
Laura E Taggart, Stephen J McMahon, Fred J Currell, Kevin M Prise, Karl T Butterworth |
Abstract |
Gold nanoparticles (GNPs), have been demonstrated as effective preclinical radiosensitising agents in a range of cell models and radiation sources. These studies have also highlighted difficulty in predicted cellular radiobiological responses mediated by GNPs, based on physical assumptions alone, and therefore suggest a significant underlying biological component of response. This study aimed to determine the role of mitochondrial function in GNP radiosensitisation. Using assays of DNA damage and mitochondrial function through levels of oxidation and loss of membrane potential, we demonstrate a potential role of mitochondria as a central biological mechanism of GNP mediated radiosensitisation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
France | 1 | <1% |
Unknown | 109 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 30 | 27% |
Researcher | 16 | 14% |
Student > Master | 14 | 13% |
Student > Bachelor | 11 | 10% |
Professor > Associate Professor | 6 | 5% |
Other | 21 | 19% |
Unknown | 13 | 12% |
Readers by discipline | Count | As % |
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Physics and Astronomy | 32 | 29% |
Biochemistry, Genetics and Molecular Biology | 15 | 14% |
Agricultural and Biological Sciences | 12 | 11% |
Medicine and Dentistry | 11 | 10% |
Chemistry | 6 | 5% |
Other | 13 | 12% |
Unknown | 22 | 20% |