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The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

Overview of attention for article published in Cancer Nanotechnology, September 2014
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Title
The role of mitochondrial function in gold nanoparticle mediated radiosensitisation
Published in
Cancer Nanotechnology, September 2014
DOI 10.1186/s12645-014-0005-7
Pubmed ID
Authors

Laura E Taggart, Stephen J McMahon, Fred J Currell, Kevin M Prise, Karl T Butterworth

Abstract

Gold nanoparticles (GNPs), have been demonstrated as effective preclinical radiosensitising agents in a range of cell models and radiation sources. These studies have also highlighted difficulty in predicted cellular radiobiological responses mediated by GNPs, based on physical assumptions alone, and therefore suggest a significant underlying biological component of response. This study aimed to determine the role of mitochondrial function in GNP radiosensitisation. Using assays of DNA damage and mitochondrial function through levels of oxidation and loss of membrane potential, we demonstrate a potential role of mitochondria as a central biological mechanism of GNP mediated radiosensitisation.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
France 1 <1%
Unknown 109 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 27%
Researcher 16 14%
Student > Master 14 13%
Student > Bachelor 11 10%
Professor > Associate Professor 6 5%
Other 21 19%
Unknown 13 12%
Readers by discipline Count As %
Physics and Astronomy 32 29%
Biochemistry, Genetics and Molecular Biology 15 14%
Agricultural and Biological Sciences 12 11%
Medicine and Dentistry 11 10%
Chemistry 6 5%
Other 13 12%
Unknown 22 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2015.
All research outputs
#15,325,572
of 22,793,427 outputs
Outputs from Cancer Nanotechnology
#83
of 160 outputs
Outputs of similar age
#130,652
of 225,941 outputs
Outputs of similar age from Cancer Nanotechnology
#2
of 3 outputs
Altmetric has tracked 22,793,427 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 160 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,941 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.