Title |
Evidence of involvement of the mannose receptor in the internalization of Streptococcus pneumoniae by Schwann cells
|
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Published in |
BMC Microbiology, August 2014
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DOI | 10.1186/s12866-014-0211-9 |
Pubmed ID | |
Authors |
Hugo Macedo-Ramos, Andre F Batista, Alvaro Carrier-Ruiz, Lucineia Alves, Silvana Allodi, Victor T Ribeiro-Resende, Lucia M Teixeira, Wagner Baetas-da-Cruz |
Abstract |
The ability of S. pneumoniae to generate infections depends on the restrictions imposed by the host's immunity, in order to prevent the bacterium from spreading from the nasopharynx to other tissues, such as the brain. Some authors claim that strains of S. pneumoniae, which fail to survive in the bloodstream, can enter the brain directly from the nasal cavity by axonal transport through the olfactory and/or trigeminal nerves. However, from the immunological point of view, glial cells are far more responsive to bacterial infections than are neurons. This hypothesis is consistent with several recent reports showing that bacteria can infect glial cells from the olfactory bulb and trigeminal ganglia. Since our group previously demonstrated that Schwann cells (SCs) express a functional and appropriately regulated mannose receptor (MR), we decided to test whether SCs are involved in the internalization of S. pneumoniae via MR. |
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Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 23% |
Student > Master | 5 | 23% |
Student > Bachelor | 3 | 14% |
Professor > Associate Professor | 3 | 14% |
Student > Postgraduate | 2 | 9% |
Other | 1 | 5% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 6 | 27% |
Immunology and Microbiology | 4 | 18% |
Medicine and Dentistry | 3 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Chemistry | 2 | 9% |
Other | 4 | 18% |
Unknown | 1 | 5% |