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Evidence of involvement of the mannose receptor in the internalization of Streptococcus pneumoniae by Schwann cells

Overview of attention for article published in BMC Microbiology, August 2014
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Title
Evidence of involvement of the mannose receptor in the internalization of Streptococcus pneumoniae by Schwann cells
Published in
BMC Microbiology, August 2014
DOI 10.1186/s12866-014-0211-9
Pubmed ID
Authors

Hugo Macedo-Ramos, Andre F Batista, Alvaro Carrier-Ruiz, Lucineia Alves, Silvana Allodi, Victor T Ribeiro-Resende, Lucia M Teixeira, Wagner Baetas-da-Cruz

Abstract

The ability of S. pneumoniae to generate infections depends on the restrictions imposed by the host's immunity, in order to prevent the bacterium from spreading from the nasopharynx to other tissues, such as the brain. Some authors claim that strains of S. pneumoniae, which fail to survive in the bloodstream, can enter the brain directly from the nasal cavity by axonal transport through the olfactory and/or trigeminal nerves. However, from the immunological point of view, glial cells are far more responsive to bacterial infections than are neurons. This hypothesis is consistent with several recent reports showing that bacteria can infect glial cells from the olfactory bulb and trigeminal ganglia. Since our group previously demonstrated that Schwann cells (SCs) express a functional and appropriately regulated mannose receptor (MR), we decided to test whether SCs are involved in the internalization of S. pneumoniae via MR.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 23%
Student > Master 5 23%
Student > Bachelor 3 14%
Professor > Associate Professor 3 14%
Student > Postgraduate 2 9%
Other 1 5%
Unknown 3 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 27%
Immunology and Microbiology 4 18%
Medicine and Dentistry 3 14%
Biochemistry, Genetics and Molecular Biology 2 9%
Chemistry 2 9%
Other 4 18%
Unknown 1 5%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2015.
All research outputs
#20,263,155
of 22,793,427 outputs
Outputs from BMC Microbiology
#2,687
of 3,187 outputs
Outputs of similar age
#193,410
of 229,755 outputs
Outputs of similar age from BMC Microbiology
#36
of 44 outputs
Altmetric has tracked 22,793,427 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,187 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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