Title |
Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4Δ53
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Published in |
Veterinary Research, March 2015
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DOI | 10.1186/s13567-015-0162-7 |
Pubmed ID | |
Authors |
Michael L Clawson, Reid Redden, Gennie Schuller, Michael P Heaton, Aspen Workman, Carol G Chitko-McKown, Timothy PL Smith, Kreg A Leymaster |
Abstract |
Small ruminant lentivirus (SRLV) infections of sheep are influenced by genetics on both the host and pathogen sides. Genetic variation in the ovine transmembrane 154 (TMEM154) gene associates with infection susceptibility, and distinct SRLV genetic subgroups infect sheep in association with their TMEM154 diplotypes. In this study, a novel SRLV subgroup was identified that naturally infected sheep with various TMEM154 diplotypes, including those homozygous for a rare frameshift mutation (A4 delta53), which is predicted to abolish TMEM154 protein function. Thus, these SRLVs may infect sheep that lack functional TMEM154, and may not be restricted by TMEM154 diplotypes in establishing infections. |
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Unknown | 5 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Scientists | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 38% |
Other | 1 | 8% |
Student > Bachelor | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Professor | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 23% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 5 | 38% |
Veterinary Science and Veterinary Medicine | 3 | 23% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Arts and Humanities | 1 | 8% |
Unknown | 3 | 23% |