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Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics

Overview of attention for article published in Cardiovascular Diabetology, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

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6 tweeters
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

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66 Dimensions

Readers on

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56 Mendeley
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Title
Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics
Published in
Cardiovascular Diabetology, January 2015
DOI 10.1186/s12933-015-0192-5
Pubmed ID
Authors

Etheresia Pretorius, Janette Bester, Natasha Vermeulen, Sajee Alummoottil, Prashilla Soma, Antoinette V Buys, Douglas B Kell

Abstract

We have noted in previous work, in a variety of inflammatory diseases, where iron dysregulation occurs, a strong tendency for erythrocytes to lose their normal discoid shape and to adopt a skewed morphology (as judged by their axial ratios in the light microscope and by their ultrastructure in the SEM). Similarly, the polymerization of fibrinogen, as induced in vitro by added thrombin, leads not to the common 'spaghetti-like' structures but to dense matted deposits. Type 2 diabetes is a known inflammatory disease. In the present work, we found that the axial ratio of the erythrocytes of poorly controlled (as suggested by increased HbA1c levels) type 2 diabetics was significantly increased, and that their fibrin morphologies were again highly aberrant. As judged by scanning electron microscopy and in the atomic force microscope, these could be reversed, to some degree, by the addition of the iron chelators deferoxamine (DFO) or deferasirox (DFX). As well as their demonstrated diagnostic significance, these morphological indicators may have prognostic value.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 55 98%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 11 20%
Student > Ph. D. Student 8 14%
Researcher 6 11%
Other 6 11%
Student > Bachelor 4 7%
Other 7 13%
Unknown 14 25%
Readers by discipline Count As %
Medicine and Dentistry 12 21%
Biochemistry, Genetics and Molecular Biology 6 11%
Agricultural and Biological Sciences 4 7%
Nursing and Health Professions 3 5%
Physics and Astronomy 2 4%
Other 9 16%
Unknown 20 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2015.
All research outputs
#2,700,300
of 11,871,430 outputs
Outputs from Cardiovascular Diabetology
#121
of 697 outputs
Outputs of similar age
#52,429
of 219,642 outputs
Outputs of similar age from Cardiovascular Diabetology
#2
of 9 outputs
Altmetric has tracked 11,871,430 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 697 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 219,642 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.