Title |
Dietary n-3 fatty acids have suppressive effects on mucin upregulation in mice infected with Pseudomonas aeruginosa
|
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Published in |
Respiratory Research, June 2007
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DOI | 10.1186/1465-9921-8-39 |
Pubmed ID | |
Authors |
Daniel Tetaert, Maud Pierre, Dominique Demeyer, Marie-Odile Husson, Laurent Béghin, Claude Galabert, Frédéric Gottrand, Christopher Beermann, Benoit Guery, Jean-Luc Desseyn |
Abstract |
Mucin hypersecretion and mucus plugging in the airways are characteristic features of chronic respiratory diseases like cystic fibrosis (CF) and contribute to morbidity and mortality. In CF, Pseudomonas aeruginosa superinfections in the lung exacerbate inflammation and alter mucus properties. There is increasing evidence that n-3 polyunsaturated fatty acids (PUFAs) exhibit anti-inflammatory properties in many inflammatory diseases while n-6 PUFA arachidonic acid (AA) favors inflammatory mediators such as eicosanoids prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) that may enhance inflammatory reactions. This suggests that n-3 PUFAs may have a protective effect against mucus over-production in airway diseases. Therefore, we hypothesized that n-3 PUFAs may downregulate mucins expression. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Ireland | 1 | 4% |
Unknown | 25 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 19% |
Student > Master | 4 | 15% |
Student > Doctoral Student | 3 | 12% |
Student > Ph. D. Student | 3 | 12% |
Student > Bachelor | 2 | 8% |
Other | 6 | 23% |
Unknown | 3 | 12% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 3 | 12% |
Medicine and Dentistry | 3 | 12% |
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Business, Management and Accounting | 1 | 4% |
Other | 3 | 12% |
Unknown | 4 | 15% |