Title |
Coma in fatal adult human malaria is not caused by cerebral oedema
|
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Published in |
Malaria Journal, September 2011
|
DOI | 10.1186/1475-2875-10-267 |
Pubmed ID | |
Authors |
Isabelle M Medana, Nicholas PJ Day, Navakanit Sachanonta, Nguyen TH Mai, Arjen M Dondorp, Emsri Pongponratn, Tran T Hien, Nicholas J White, Gareth DH Turner |
Abstract |
The role of brain oedema in the pathophysiology of cerebral malaria is controversial. Coma associated with severe Plasmodium falciparum malaria is multifactorial, but associated with histological evidence of parasitized erythrocyte sequestration and resultant microvascular congestion in cerebral vessels. To determine whether these changes cause breakdown of the blood-brain barrier and resultant perivascular or parenchymal cerebral oedema, histology, immunohistochemistry and image analysis were used to define the prevalence of histological patterns of oedema and the expression of specific molecular pathways involved in water balance in the brain in adults with fatal falciparum malaria. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Denmark | 1 | 1% |
Pakistan | 1 | 1% |
Nigeria | 1 | 1% |
Unknown | 90 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 22% |
Researcher | 16 | 17% |
Student > Master | 15 | 16% |
Student > Bachelor | 8 | 9% |
Professor | 5 | 5% |
Other | 16 | 17% |
Unknown | 13 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 30% |
Agricultural and Biological Sciences | 27 | 29% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
Immunology and Microbiology | 5 | 5% |
Biochemistry, Genetics and Molecular Biology | 4 | 4% |
Other | 8 | 9% |
Unknown | 15 | 16% |