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Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells

Overview of attention for article published in Cancer & Metabolism, March 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#35 of 204)
  • High Attention Score compared to outputs of the same age (87th percentile)

Mentioned by

news
1 news outlet
patent
1 patent
facebook
1 Facebook page

Citations

dimensions_citation
88 Dimensions

Readers on

mendeley
108 Mendeley
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Title
Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
Published in
Cancer & Metabolism, March 2013
DOI 10.1186/2049-3002-1-12
Pubmed ID
Authors

Liang Zheng, Elaine D MacKenzie, Saadia A Karim, Ann Hedley, Karen Blyth, Gabriela Kalna, David G Watson, Peter Szlosarek, Christian Frezza, Eyal Gottlieb

Abstract

Loss of function of fumarate hydratase (FH), the mitochondrial tumor suppressor and tricarboxylic acid (TCA) cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell cancer. The accumulation of fumarate in these cells has been linked to the tumorigenic process. However, little is known about the overall effects of the loss of FH on cellular metabolism.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
United States 1 <1%
Unknown 106 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 21%
Researcher 23 21%
Student > Bachelor 10 9%
Student > Master 8 7%
Other 5 5%
Other 13 12%
Unknown 26 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 32 30%
Agricultural and Biological Sciences 27 25%
Medicine and Dentistry 8 7%
Chemistry 5 5%
Immunology and Microbiology 2 2%
Other 7 6%
Unknown 27 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2016.
All research outputs
#2,874,921
of 22,794,367 outputs
Outputs from Cancer & Metabolism
#35
of 204 outputs
Outputs of similar age
#24,826
of 197,775 outputs
Outputs of similar age from Cancer & Metabolism
#2
of 4 outputs
Altmetric has tracked 22,794,367 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 204 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,775 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.