Title |
IL-10 Mediated by Herpes Simplex Virus Vector Reduces Neuropathic Pain Induced by HIV gp120 Combined with ddC in Rats
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Published in |
Molecular Pain, January 2014
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DOI | 10.1186/1744-8069-10-49 |
Pubmed ID | |
Authors |
Wenwen Zheng, Wan Huang, Shue Liu, Roy C Levitt, Keith A Candiotti, David A Lubarsky, Shuanglin Hao |
Abstract |
HIV-associated sensory neuropathy affects over 50% of HIV patients and is a common peripheral nerve complication of HIV infection and highly active antiretroviral therapy (HAART). Evidence shows that painful HIV sensory neuropathy is influenced by neuroinflammatory events that include the proinflammatory molecules, MAP Kinase, tumor necrosis factor-α (TNFα), stromal cell-derived factor 1-α (SDF1α), and C-X-C chemokine receptor type 4 (CXCR4). However, the exact mechanisms of painful HIV sensory neuropathy are not known, which hinders our ability to develop effective treatments. In this study, we investigated whether inhibition of proinflammatory factors reduces the HIV-associated neuropathic pain state. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 4% |
Unknown | 27 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 18% |
Researcher | 3 | 11% |
Student > Ph. D. Student | 3 | 11% |
Lecturer | 2 | 7% |
Student > Doctoral Student | 2 | 7% |
Other | 6 | 21% |
Unknown | 7 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 25% |
Agricultural and Biological Sciences | 3 | 11% |
Neuroscience | 2 | 7% |
Nursing and Health Professions | 1 | 4% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Other | 4 | 14% |
Unknown | 10 | 36% |