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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Therapeutic applications of mesenchymal stem cells for amyotrophic lateral sclerosis
|
|---|---|
| Published in |
Stem Cell Research & Therapy, March 2014
|
| DOI | 10.1186/scrt421 |
| Pubmed ID | |
| Authors |
Christina M Lewis, Masatoshi Suzuki |
| Abstract |
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the neuromuscular system and does not have a known singular cause. Genetic mutations, extracellular factors, non-neuronal support cells, and the immune system have all been shown to play varied roles in clinical and pathological disease progression. The therapeutic plasticity of mesenchymal stem cells (MSCs) may be well matched to this complex disease pathology, making MSCs strong candidates for cellular therapy in ALS. In this review, we summarize a variety of explored mechanisms by which MSCs play a role in ALS progression, including neuronal and non-neuronal cell replacement, trophic factor delivery, and modulation of the immune system. Currently relevant techniques for applying MSC therapy in ALS are discussed, focusing in particular on delivery route and cell source. We include examples from in vitro, preclinical, and clinical investigations to elucidate the remaining progress that must be made to understand and apply MSCs as a treatment for ALS. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 103 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 18 | 17% |
| Student > Ph. D. Student | 13 | 12% |
| Student > Master | 13 | 12% |
| Researcher | 9 | 8% |
| Other | 7 | 7% |
| Other | 17 | 16% |
| Unknown | 29 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 23% |
| Medicine and Dentistry | 19 | 18% |
| Biochemistry, Genetics and Molecular Biology | 14 | 13% |
| Neuroscience | 3 | 3% |
| Nursing and Health Professions | 2 | 2% |
| Other | 12 | 11% |
| Unknown | 32 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2019.
All research outputs
#13,196,442
of 22,794,367 outputs
Outputs from Stem Cell Research & Therapy
#910
of 2,418 outputs
Outputs of similar age
#107,559
of 221,360 outputs
Outputs of similar age from Stem Cell Research & Therapy
#19
of 32 outputs
Altmetric has tracked 22,794,367 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,418 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,360 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.