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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genetic polymorphisms linked to susceptibility to malaria
|
|---|---|
| Published in |
Malaria Journal, September 2011
|
| DOI | 10.1186/1475-2875-10-271 |
| Pubmed ID | |
| Authors |
Adel Driss, Jacqueline M Hibbert, Nana O Wilson, Shareen A Iqbal, Thomas V Adamkiewicz, Jonathan K Stiles |
| Abstract |
The influence of host genetics on susceptibility to Plasmodium falciparum malaria has been extensively studied over the past twenty years. It is now clear that malaria parasites have imposed strong selective forces on the human genome in endemic regions. Different genes have been identified that are associated with different malaria related phenotypes. Factors that promote severity of malaria include parasitaemia, parasite induced inflammation, anaemia and sequestration of parasitized erythrocytes in brain microvasculature.Recent advances in human genome research technologies such as genome-wide association studies (GWAS) and fine genotyping tools have enabled the discovery of several genetic polymorphisms and biomarkers that warrant further study in host-parasite interactions. This review describes and discusses human gene polymorphisms identified thus far that have been shown to be associated with susceptibility or resistance to P. falciparum malaria. Although some polymorphisms play significant roles in susceptibility to malaria, several findings are inconclusive and contradictory and must be considered with caution. The discovery of genetic markers associated with different malaria phenotypes will help elucidate the pathophysiology of malaria and enable development of interventions or cures. Diversity in human populations as well as environmental effects can influence the clinical heterogeneity of malaria, thus warranting further investigations with a goal of developing new interventions, therapies and better management against malaria. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 283 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | <1% |
| Tanzania, United Republic of | 2 | <1% |
| Germany | 1 | <1% |
| Indonesia | 1 | <1% |
| France | 1 | <1% |
| Pakistan | 1 | <1% |
| Portugal | 1 | <1% |
| Kenya | 1 | <1% |
| Brazil | 1 | <1% |
| Other | 6 | 2% |
| Unknown | 266 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 67 | 24% |
| Student > Master | 45 | 16% |
| Student > Bachelor | 34 | 12% |
| Researcher | 30 | 11% |
| Student > Postgraduate | 19 | 7% |
| Other | 48 | 17% |
| Unknown | 40 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 87 | 31% |
| Biochemistry, Genetics and Molecular Biology | 51 | 18% |
| Medicine and Dentistry | 51 | 18% |
| Immunology and Microbiology | 19 | 7% |
| Chemistry | 4 | 1% |
| Other | 21 | 7% |
| Unknown | 50 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2011.
All research outputs
#18,295,723
of 22,651,245 outputs
Outputs from Malaria Journal
#5,008
of 5,533 outputs
Outputs of similar age
#108,558
of 130,474 outputs
Outputs of similar age from Malaria Journal
#59
of 64 outputs
Altmetric has tracked 22,651,245 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,533 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,474 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.