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Cyclic Phosphatidic Acid Relieves Osteoarthritis Symptoms

Overview of attention for article published in Molecular Pain, January 2014
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Title
Cyclic Phosphatidic Acid Relieves Osteoarthritis Symptoms
Published in
Molecular Pain, January 2014
DOI 10.1186/1744-8069-10-52
Pubmed ID
Authors

Mari Gotoh, Aya Nagano, Ryoko Tsukahara, Hiromu Murofushi, Toshiro Morohoshi, Kazuyuki Otsuka, Kimiko Murakami-Murofushi

Abstract

Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator with a unique cyclic phosphate ring at the sn-2 and sn-3 positions of its glycerol backbone. Natural cPA and its chemically stabilized cPA derivative, 2-carba-cPA (2ccPA), inhibit chronic and acute inflammation, and 2ccPA attenuates neuropathic pain. Osteoarthritis (OA) is a degenerative disease frequently associated with symptoms such as inflammation and joint pain. Because 2ccPA has obvious antinociceptive activity, we hypothesized that 2ccPA might relieve the pain caused by OA. We aimed to characterize the effects of 2ccPA on the pathogenesis of OA induced by total meniscectomy in the rabbit knee joint.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 51 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 16%
Student > Bachelor 5 10%
Other 4 8%
Researcher 4 8%
Student > Doctoral Student 3 6%
Other 16 31%
Unknown 11 22%
Readers by discipline Count As %
Medicine and Dentistry 10 20%
Biochemistry, Genetics and Molecular Biology 6 12%
Agricultural and Biological Sciences 4 8%
Nursing and Health Professions 3 6%
Immunology and Microbiology 2 4%
Other 9 18%
Unknown 17 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2015.
All research outputs
#22,758,309
of 25,371,288 outputs
Outputs from Molecular Pain
#595
of 669 outputs
Outputs of similar age
#280,461
of 319,271 outputs
Outputs of similar age from Molecular Pain
#51
of 58 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,271 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.