Title |
Cyclic Phosphatidic Acid Relieves Osteoarthritis Symptoms
|
---|---|
Published in |
Molecular Pain, January 2014
|
DOI | 10.1186/1744-8069-10-52 |
Pubmed ID | |
Authors |
Mari Gotoh, Aya Nagano, Ryoko Tsukahara, Hiromu Murofushi, Toshiro Morohoshi, Kazuyuki Otsuka, Kimiko Murakami-Murofushi |
Abstract |
Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator with a unique cyclic phosphate ring at the sn-2 and sn-3 positions of its glycerol backbone. Natural cPA and its chemically stabilized cPA derivative, 2-carba-cPA (2ccPA), inhibit chronic and acute inflammation, and 2ccPA attenuates neuropathic pain. Osteoarthritis (OA) is a degenerative disease frequently associated with symptoms such as inflammation and joint pain. Because 2ccPA has obvious antinociceptive activity, we hypothesized that 2ccPA might relieve the pain caused by OA. We aimed to characterize the effects of 2ccPA on the pathogenesis of OA induced by total meniscectomy in the rabbit knee joint. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 16% |
Student > Bachelor | 5 | 10% |
Other | 4 | 8% |
Researcher | 4 | 8% |
Student > Doctoral Student | 3 | 6% |
Other | 16 | 31% |
Unknown | 11 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 20% |
Biochemistry, Genetics and Molecular Biology | 6 | 12% |
Agricultural and Biological Sciences | 4 | 8% |
Nursing and Health Professions | 3 | 6% |
Immunology and Microbiology | 2 | 4% |
Other | 9 | 18% |
Unknown | 17 | 33% |