Title |
Liver and muscle hemojuvelin are differently glycosylated
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Published in |
BMC Molecular and Cell Biology, September 2011
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DOI | 10.1186/1471-2091-12-52 |
Pubmed ID | |
Authors |
Yuzo Fujikura, Jan Krijt, Emanuel Nečas |
Abstract |
Hemojuvelin (HJV) is one of essential components for expression of hepcidin, a hormone which regulates iron transport. HJV is mainly expressed in muscle and liver, and processing of HJV in both tissues is similar. However, hepcidin is expressed in liver but not in muscle and the role of the muscle HJV is yet to be established. Our preliminary analyses of mouse tissue HJV showed that the apparent molecular masses of HJV peptides are different in liver (50 kDa monomer and 35 and 20 kDa heterodimer fragments) and in muscle (55 kDa monomer and a 34 kDa possible large fragment of heterodimer). One possible explanation is glycosylation which could lead to difference in molecular mass. |
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