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The role of flavor and fragrance chemicals in TRPA1 (transient receptor potential cation channel, member A1) activity associated with allergies

Overview of attention for article published in Allergy, Asthma & Clinical Immunology, March 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

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1 news outlet
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21 X users

Citations

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43 Dimensions

Readers on

mendeley
108 Mendeley
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Title
The role of flavor and fragrance chemicals in TRPA1 (transient receptor potential cation channel, member A1) activity associated with allergies
Published in
Allergy, Asthma & Clinical Immunology, March 2015
DOI 10.1186/s13223-015-0074-0
Pubmed ID
Authors

Satoru Mihara, Takayuki Shibamoto

Abstract

TRPA1 has been proposed to be associated with diverse sensory allergic reactions, including thermal (cold) nociception, hearing and allergic inflammatory conditions. Some naturally occurring compounds are known to activate TRPA1 by forming a Michael addition product with a cysteine residue of TRPA1 through covalent protein modification and, in consequence, to cause allergic reactions. The anti-allergic property of TRPA1 agonists may be due to the activation and subsequent desensitization of TRPA1 expressed in sensory neurons. In this review, naturally occurring TRPA1 antagonists, such as camphor, 1,8-cineole, menthol, borneol, fenchyl alcohol and 2-methylisoborneol, and TRPA1 agonists, including thymol, carvacrol, 1'S-1'- acetoxychavicol acetate, cinnamaldehyde, α-n-hexyl cinnamic aldehyde and thymoquinone as well as isothiocyanates and sulfides are discussed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 108 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 19%
Student > Master 15 14%
Student > Ph. D. Student 14 13%
Student > Doctoral Student 9 8%
Other 8 7%
Other 20 19%
Unknown 22 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 17%
Biochemistry, Genetics and Molecular Biology 15 14%
Pharmacology, Toxicology and Pharmaceutical Science 13 12%
Medicine and Dentistry 12 11%
Chemistry 8 7%
Other 14 13%
Unknown 28 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2019.
All research outputs
#1,583,622
of 25,643,886 outputs
Outputs from Allergy, Asthma & Clinical Immunology
#85
of 926 outputs
Outputs of similar age
#19,931
of 278,607 outputs
Outputs of similar age from Allergy, Asthma & Clinical Immunology
#2
of 11 outputs
Altmetric has tracked 25,643,886 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 926 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,607 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.