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Transfusion of red cells in hematopoietic stem cell transplantation (TRIST): study protocol for a randomized controlled trial

Overview of attention for article published in Trials, September 2011
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Title
Transfusion of red cells in hematopoietic stem cell transplantation (TRIST): study protocol for a randomized controlled trial
Published in
Trials, September 2011
DOI 10.1186/1745-6215-12-207
Pubmed ID
Authors

Jason Tay, Alan Tinmouth, Dean Fergusson, David Allan

Abstract

Insight regarding transfusion practices in Hematopoietic Stem cell Transplantation (HSCT) are lacking and the impact of red cell transfusion in this high risk group on outcomes following HSCT are not well appreciated. Red blood cell transfusion can be life-saving, however, liberal use of transfusion in critically ill patients failed to demonstrate significant clinical benefit. A large number of other observational studies have also demonstrated an association between red blood cell transfusions and increased morbidity such as infections and multi organ failure as well as increased mortality. The role of red cell transfusion on the clinical outcomes observed in patients undergoing HSCT remains poorly understood and a prospective randomized study of transfusion is required to gain insight and knowledge on best transfusion practices in this high risk population.

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Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Switzerland 1 2%
Unknown 58 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 15%
Student > Master 8 13%
Other 7 11%
Student > Ph. D. Student 4 7%
Student > Postgraduate 4 7%
Other 12 20%
Unknown 17 28%
Readers by discipline Count As %
Medicine and Dentistry 28 46%
Nursing and Health Professions 4 7%
Psychology 2 3%
Agricultural and Biological Sciences 2 3%
Business, Management and Accounting 1 2%
Other 6 10%
Unknown 18 30%