Title |
Transcription factor myocyte enhancer factor 2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death
|
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Published in |
Journal of Neuroinflammation, January 2015
|
DOI | 10.1186/s12974-015-0258-z |
Pubmed ID | |
Authors |
Shaosong Yang, Li Gao, Fangfang Lu, Bao Wang, Fei Gao, Gang Zhu, Zhibiao Cai, Juan Lai, Qian Yang |
Abstract |
Neuroinflammatory responses have been recognized as an important aspect in the pathogenesis of Parkinson's disease (PD). Transcriptional regulation plays a critical role in the process of inflammation. Transcription factor myocyte enhancer factor 2D (MEF2D) is identified as a central factor in transmission of extracellular signals and activation of the genetic programs in response to a wide range of stimuli in several cell types, including neurons. But its presence and function in microglia have not been reported. We therefore investigated the effect of MEF2D in activated microglia on the progress of neuroinflammation and the survival of neurons. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 61 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 23% |
Student > Bachelor | 14 | 23% |
Student > Master | 8 | 13% |
Researcher | 5 | 8% |
Student > Doctoral Student | 4 | 6% |
Other | 5 | 8% |
Unknown | 12 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 26% |
Biochemistry, Genetics and Molecular Biology | 9 | 15% |
Neuroscience | 7 | 11% |
Medicine and Dentistry | 6 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 7 | 11% |
Unknown | 14 | 23% |