Title |
Ipilimumab and immune-mediated adverse events: a case report of anti-CTLA4 induced ileitis
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Published in |
BMC Cancer, March 2015
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DOI | 10.1186/s12885-015-1074-7 |
Pubmed ID | |
Authors |
Olga Venditti, Delia De Lisi, Marco Caricato, Damiano Caputo, Gabriella Teresa Capolupo, Chiara Taffon, Elisa Pagliara, Sofia Battisi, Anna Maria Frezza, Andrea Onetti Muda, Giuseppe Tonini, Daniele Santini |
Abstract |
Ipilimumab is a fully human monoclonal antibody directed against cytotoxic T-lymphocyte antigen-4 , a key negative regulator of T-cell activation approved by the Food and Drug Administration as of March 2011 for the treatment of metastatic melanoma. As a result of the up-regulation of the immune system, several immune-mediated adverse effects have been reported including colitis, dermatitis, hepatitis and rarely hypophysitis. The most frequent immune-mediated adverse effects described in literature include gastrointestinal toxicity such as diarrhea, colitis and case of colitis and ileitis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 24% |
Student > Bachelor | 5 | 14% |
Student > Doctoral Student | 3 | 8% |
Researcher | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Other | 7 | 19% |
Unknown | 7 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 51% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Agricultural and Biological Sciences | 2 | 5% |
Immunology and Microbiology | 2 | 5% |
Nursing and Health Professions | 1 | 3% |
Other | 3 | 8% |
Unknown | 8 | 22% |