Title |
Adeno-associated virus type 2 infection activates caspase dependent and independent apoptosis in multiple breast cancer lines but not in normal mammary epithelial cells
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Published in |
Molecular Cancer, August 2011
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DOI | 10.1186/1476-4598-10-97 |
Pubmed ID | |
Authors |
Samina Alam, Brian S Bowser, Michael J Conway, Mohd Israr, Apurva Tandon, Craig Meyers |
Abstract |
In normal cells proliferation and apoptosis are tightly regulated, whereas in tumor cells the balance is shifted in favor of increased proliferation and reduced apoptosis. Anticancer agents mediate tumor cell death via targeting multiple pathways of programmed cell death. We have reported that the non-pathogenic, tumor suppressive Adeno-Associated Virus Type 2 (AAV2) induces apoptosis in Human Papillomavirus (HPV) positive cervical cancer cells, but not in normal keratinocytes. In the current study, we examined the potential of AAV2 to inhibit proliferation of MCF-7 and MDA-MB-468 (both weakly invasive), as well as MDA-MB-231 (highly invasive) human breast cancer derived cell lines. As controls, we used normal human mammary epithelial cells (nHMECs) isolated from tissue biopsies of patients undergoing breast reduction surgery. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 4% |
Unknown | 53 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 31% |
Researcher | 9 | 16% |
Student > Master | 6 | 11% |
Student > Bachelor | 4 | 7% |
Professor > Associate Professor | 3 | 5% |
Other | 7 | 13% |
Unknown | 9 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 35% |
Medicine and Dentistry | 9 | 16% |
Engineering | 5 | 9% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Neuroscience | 4 | 7% |
Other | 6 | 11% |
Unknown | 8 | 15% |