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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Fate determination in mesenchymal stem cells: a perspective from histone-modifying enzymes
|
|---|---|
| Published in |
Stem Cell Research & Therapy, March 2015
|
| DOI | 10.1186/s13287-015-0018-0 |
| Pubmed ID | |
| Authors |
Biao Huang, Gang Li, Xiao Hua Jiang |
| Abstract |
Mesenchymal stem cells (MSCs) hold great promise for therapeutic use in regenerative medicine and tissue engineering. A detailed understanding of the molecular processes governing MSC fate determination will be instrumental in the application of MSCs. Much progress has been made in recent years in defining the epigenetic events that control the differentiation of MSCs into different lineages. A complex network of transcription factors and histone modifiers, in concert with specific transcriptional co-activators and co-repressors, activates or represses MSC differentiation. In this review, we summarize recent progress in determining the effects of histone-modifying enzymes on the multilineage differentiation of MSCs. In addition, we propose that the manipulation of histone signatures associated with lineage-specific differentiation by small molecules has immense potential for the advancement of MSC-based regenerative medicine. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 67 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 28% |
| Student > Ph. D. Student | 13 | 19% |
| Student > Bachelor | 12 | 17% |
| Researcher | 7 | 10% |
| Professor > Associate Professor | 4 | 6% |
| Other | 6 | 9% |
| Unknown | 8 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 21 | 30% |
| Agricultural and Biological Sciences | 15 | 22% |
| Medicine and Dentistry | 9 | 13% |
| Engineering | 6 | 9% |
| Neuroscience | 3 | 4% |
| Other | 5 | 7% |
| Unknown | 10 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2015.
All research outputs
#13,355,137
of 22,796,179 outputs
Outputs from Stem Cell Research & Therapy
#948
of 2,418 outputs
Outputs of similar age
#126,637
of 263,733 outputs
Outputs of similar age from Stem Cell Research & Therapy
#27
of 64 outputs
Altmetric has tracked 22,796,179 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,418 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,733 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.