Title |
The development and maintenance of the mononuclear phagocyte system of the chick is controlled by signals from the macrophage colony-stimulating factor receptor
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Published in |
BMC Biology, February 2015
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DOI | 10.1186/s12915-015-0121-9 |
Pubmed ID | |
Authors |
Valerie Garceau, Adam Balic, Carla Garcia-Morales, Kristin A Sauter, Mike J McGrew, Jacqueline Smith, Lonneke Vervelde, Adrian Sherman, Troy E Fuller, Theodore Oliphant, John A Shelley, Raksha Tiwari, Thomas L Wilson, Cosmin Chintoan-Uta, Dave W Burt, Mark P Stevens, Helen M Sang, David A Hume |
Abstract |
Macrophages have many functions in development and homeostasis as well as innate immunity. Recent studies in mammals suggest that cells arising in the yolk sac give rise to self-renewing macrophage populations that persist in adult tissues. Macrophage proliferation and differentiation is controlled by macrophage colony-stimulating factor (CSF1) and interleukin 34 (IL34), both agonists of the CSF1 receptor (CSF1R). In the current manuscript we describe the origin, function and regulation of macrophages, and the role of CSF1R signalling during embryonic development, using the chick as a model. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 2% |
Unknown | 65 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 21% |
Student > Master | 9 | 14% |
Student > Bachelor | 8 | 12% |
Researcher | 8 | 12% |
Student > Doctoral Student | 5 | 8% |
Other | 9 | 14% |
Unknown | 13 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 23% |
Biochemistry, Genetics and Molecular Biology | 9 | 14% |
Medicine and Dentistry | 7 | 11% |
Immunology and Microbiology | 7 | 11% |
Neuroscience | 5 | 8% |
Other | 11 | 17% |
Unknown | 12 | 18% |