Title |
Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects
|
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Published in |
AIDS Research and Therapy, April 2006
|
DOI | 10.1186/1742-6405-3-12 |
Pubmed ID | |
Authors |
Li Wan, Xiaoping Zhang, Simi Gunaseelan, Shahriar Pooyan, Olivia Debrah, Michael J Leibowitz, Arnold B Rabson, Stanley Stein, Patrick J Sinko |
Abstract |
Current anti-AIDS therapeutic agents and treatment regimens can provide a dramatically improved quality of life for HIV-positive people, many of whom have no detectable viral load for prolonged periods of time. Despite this, curing AIDS remains an elusive goal, partially due to the occurrence of drug resistance. Since the development of resistance is linked to, among other things, fluctuating drug levels, our long-term goal has been to develop nanotechnology-based drug delivery systems that can improve therapy by more precisely controlling drug concentrations in target cells. The theme of the current study is to investigate the value of combining AIDS drugs and modifiers of cellular uptake into macromolecular conjugates having novel pharmacological properties. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 5% |
Unknown | 20 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 33% |
Student > Ph. D. Student | 5 | 24% |
Professor | 4 | 19% |
Student > Master | 2 | 10% |
Student > Doctoral Student | 1 | 5% |
Other | 1 | 5% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 29% |
Medicine and Dentistry | 5 | 24% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 14% |
Chemistry | 3 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Other | 2 | 10% |