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Genomics driven-oncology: challenges and perspectives

Overview of attention for article published in BMC Cancer, March 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters

Citations

dimensions_citation
5 Dimensions

Readers on

mendeley
14 Mendeley
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Title
Genomics driven-oncology: challenges and perspectives
Published in
BMC Cancer, March 2015
DOI 10.1186/s12885-015-1147-7
Pubmed ID
Authors

Nicola Normanno, Ian A Cree

Abstract

Molecularly defined subgroups of tumors characterized by specific driver mutations have been identified in the majority of cancers. The availability of novel drugs capable of targeting signaling pathways activated by genetic derangements has led to hypothesize the possibility to treat patients based on their genomic profile. A clear example is represented by lung adenocarcinoma for which it has been possible to identify driver genetic alterations in approximately 75% of the cases. Among these, RET fusion transcripts are detectable in about 1-2% of lung adenocarcinomas and might represent targets for therapeutic intervention with RET kinase inhibitors. However, a number of issues need to be addressed to make genomics-driven oncology routinely accessible for cancer patients, including: 1) the availability of novel methods in molecular diagnostics that allow a comprehensive molecular characterization of lung tumors starting from a low input DNA/RNA; 2) identification of reliable and reproducible biomarkers of response/resistance to targeted agents; 3) the assessment of the role of tumor heterogeneity in the response to drugs targeting molecular pathways.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 36%
Researcher 3 21%
Other 1 7%
Professor 1 7%
Student > Doctoral Student 1 7%
Other 2 14%
Unknown 1 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 29%
Medicine and Dentistry 4 29%
Biochemistry, Genetics and Molecular Biology 2 14%
Nursing and Health Professions 1 7%
Decision Sciences 1 7%
Other 1 7%
Unknown 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2015.
All research outputs
#610,270
of 4,946,498 outputs
Outputs from BMC Cancer
#162
of 2,784 outputs
Outputs of similar age
#28,158
of 146,289 outputs
Outputs of similar age from BMC Cancer
#14
of 137 outputs
Altmetric has tracked 4,946,498 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,784 research outputs from this source. They receive a mean Attention Score of 2.6. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,289 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 137 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.