Title |
Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway
|
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Published in |
Arthritis Research & Therapy, June 2011
|
DOI | 10.1186/ar3367 |
Pubmed ID | |
Authors |
Valentina Ulivi, Manuela Lenti, Chiara Gentili, Gabriele Marcolongo, Ranieri Cancedda, Fiorella Descalzi Cancedda |
Abstract |
The mono- and digalactosyldiacylglycerol (MGDG and DGDG) galactolipids have been purified from the thermophilic blue-green alga Phormidium sp. ETS-05 that colonizes the therapeutic thermal mud of Abano Terme and Montegrotto Terme, Italy. Both compounds present a marked composition in polyunsaturated fatty acids, mainly omega-3. The therapeutic thermal mud is applied mainly to osteoarthritic cartilage patients. In the present study the effect of MGDG treatment on proteins and factors expressed by human articular cartilage cells in culture and on pathways activated in inflammatory conditions was studied. |
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Demographic breakdown
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