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Hypermutation takes the driver’s seat

Overview of attention for article published in Genome Medicine, March 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)

Mentioned by

twitter
11 tweeters
patent
4 patents
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
15 Dimensions

Readers on

mendeley
28 Mendeley
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Title
Hypermutation takes the driver’s seat
Published in
Genome Medicine, March 2015
DOI 10.1186/s13073-015-0159-x
Pubmed ID
Authors

Matthias Schlesner, Roland Eils

Abstract

Most pediatric tumors have only very few somatic mutations. However, a recent study revealed that a subset of tumors from children with congenital biallelic deficiency of DNA mismatch repair exhibits a mutational load surpassing almost all other cancers. In these ultra-hypermutated tumors, somatic mutations in the proofreading DNA polymerases complement the congenital mismatch repair deficiency to completely abolish replication repair, thereby driving tumor development. These findings open several possibilities for exploiting ultra-hypermutation for cancer therapy.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 4%
Australia 1 4%
Unknown 26 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 29%
Researcher 8 29%
Student > Bachelor 3 11%
Student > Master 2 7%
Other 2 7%
Other 4 14%
Unknown 1 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 50%
Biochemistry, Genetics and Molecular Biology 6 21%
Medicine and Dentistry 3 11%
Computer Science 2 7%
Mathematics 1 4%
Other 1 4%
Unknown 1 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2020.
All research outputs
#1,608,984
of 19,441,086 outputs
Outputs from Genome Medicine
#361
of 1,287 outputs
Outputs of similar age
#24,278
of 235,522 outputs
Outputs of similar age from Genome Medicine
#1
of 1 outputs
Altmetric has tracked 19,441,086 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,287 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,522 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them