Title |
Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study
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Published in |
BMC Psychiatry, March 2015
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DOI | 10.1186/s12888-015-0435-8 |
Pubmed ID | |
Authors |
Umberto Albert, Giuseppe Maina, Andrea Aguglia, Alberto Vitalucci, Filippo Bogetto, Chiara Fronda, Alessandro Ducati, Michele Lanotte |
Abstract |
Limited therapeutic options are available for patients with treatment-refractory major depression who do not respond to routinely available therapies. Vagus nerve stimulation showed adjunctive antidepressant effect in chronic treatment resistant depression, even though available studies rarely exceed 2-year follow up. We report a naturalistic 5-year follow up of five patients who received VNS implant for resistant depression (3 patients with major depressive disorder and 2 with bipolar disorder). Response was defined as a reduction of the 17-item HDRS total score ≥50% with respect to baseline, remission as a score ≤7. Response and remission rates were both 40% (2/5) after 1 year, and 60% (3/5) at 5 years. Two patients withdrew from the study because of side effects or inefficacy of stimulation. Our case series showed that long-term VNS may be effective in reducing severity of depression in a small but significant minority of patients, although two patients had stimulation terminated because of adverse effects and/or refusal to continue the study. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Greece | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 99 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 20% |
Student > Master | 13 | 13% |
Student > Bachelor | 13 | 13% |
Researcher | 8 | 8% |
Other | 5 | 5% |
Other | 18 | 18% |
Unknown | 22 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 28 | 28% |
Neuroscience | 15 | 15% |
Agricultural and Biological Sciences | 7 | 7% |
Psychology | 6 | 6% |
Nursing and Health Professions | 3 | 3% |
Other | 12 | 12% |
Unknown | 28 | 28% |