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Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study

Overview of attention for article published in BMC Psychiatry, March 2015
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Title
Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study
Published in
BMC Psychiatry, March 2015
DOI 10.1186/s12888-015-0435-8
Pubmed ID
Authors

Umberto Albert, Giuseppe Maina, Andrea Aguglia, Alberto Vitalucci, Filippo Bogetto, Chiara Fronda, Alessandro Ducati, Michele Lanotte

Abstract

Limited therapeutic options are available for patients with treatment-refractory major depression who do not respond to routinely available therapies. Vagus nerve stimulation showed adjunctive antidepressant effect in chronic treatment resistant depression, even though available studies rarely exceed 2-year follow up. We report a naturalistic 5-year follow up of five patients who received VNS implant for resistant depression (3 patients with major depressive disorder and 2 with bipolar disorder). Response was defined as a reduction of the 17-item HDRS total score ≥50% with respect to baseline, remission as a score ≤7. Response and remission rates were both 40% (2/5) after 1 year, and 60% (3/5) at 5 years. Two patients withdrew from the study because of side effects or inefficacy of stimulation. Our case series showed that long-term VNS may be effective in reducing severity of depression in a small but significant minority of patients, although two patients had stimulation terminated because of adverse effects and/or refusal to continue the study.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 99 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 20%
Student > Master 13 13%
Student > Bachelor 13 13%
Researcher 8 8%
Other 5 5%
Other 18 18%
Unknown 22 22%
Readers by discipline Count As %
Medicine and Dentistry 28 28%
Neuroscience 15 15%
Agricultural and Biological Sciences 7 7%
Psychology 6 6%
Nursing and Health Professions 3 3%
Other 12 12%
Unknown 28 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2015.
All research outputs
#14,219,838
of 22,797,621 outputs
Outputs from BMC Psychiatry
#3,047
of 4,682 outputs
Outputs of similar age
#139,765
of 264,714 outputs
Outputs of similar age from BMC Psychiatry
#54
of 94 outputs
Altmetric has tracked 22,797,621 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,682 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.9. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,714 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.