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The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

Overview of attention for article published in BMC Medicine, April 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)

Mentioned by

1 blog
49 tweeters
1 patent
29 Facebook pages
1 Google+ user


159 Dimensions

Readers on

381 Mendeley
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The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
Published in
BMC Medicine, April 2015
DOI 10.1186/s12916-015-0310-y
Pubmed ID

Gerwyn Morris, Michael Berk


Mitochondrial dysfunction and defects in oxidative metabolism are a characteristic feature of many chronic illnesses not currently classified as mitochondrial diseases. Examples of such illnesses include bipolar disorder, multiple sclerosis, Parkinson's disease, schizophrenia, depression, autism, and chronic fatigue syndrome. While the majority of patients with multiple sclerosis appear to have widespread mitochondrial dysfunction and impaired ATP production, the findings in patients diagnosed with Parkinson's disease, autism, depression, bipolar disorder schizophrenia and chronic fatigue syndrome are less consistent, likely reflecting the fact that these diagnoses do not represent a disease with a unitary pathogenesis and pathophysiology. However, investigations have revealed the presence of chronic oxidative stress to be an almost invariant finding in study cohorts of patients afforded each diagnosis. This state is characterized by elevated reactive oxygen and nitrogen species and/or reduced levels of glutathione, and goes hand in hand with chronic systemic inflammation with elevated levels of pro-inflammatory cytokines. This paper details mechanisms by which elevated levels of reactive oxygen and nitrogen species together with elevated pro-inflammatory cytokines could conspire to pave a major road to the development of mitochondrial dysfunction and impaired oxidative metabolism seen in many patients diagnosed with these disorders.

Twitter Demographics

The data shown below were collected from the profiles of 49 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 381 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Australia 1 <1%
Brazil 1 <1%
Italy 1 <1%
Canada 1 <1%
United Kingdom 1 <1%
Mexico 1 <1%
Luxembourg 1 <1%
Unknown 371 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 70 18%
Student > Master 56 15%
Student > Ph. D. Student 50 13%
Student > Bachelor 48 13%
Other 27 7%
Other 84 22%
Unknown 46 12%
Readers by discipline Count As %
Medicine and Dentistry 99 26%
Agricultural and Biological Sciences 59 15%
Neuroscience 45 12%
Biochemistry, Genetics and Molecular Biology 32 8%
Psychology 24 6%
Other 63 17%
Unknown 59 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 46. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2021.
All research outputs
of 21,689,971 outputs
Outputs from BMC Medicine
of 3,176 outputs
Outputs of similar age
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Outputs of similar age from BMC Medicine
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Altmetric has tracked 21,689,971 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,176 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,663 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them