Title |
Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis
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Published in |
Molecular Cancer, August 2010
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DOI | 10.1186/1476-4598-9-206 |
Pubmed ID | |
Authors |
Pawan Kumar, Arti Yadav, Samip N Patel, Mozaffarul Islam, Quintin Pan, Sofia D Merajver, Theodoros N Teknos |
Abstract |
The metastatic spread of solid tumors is directly or indirectly responsible for most cancer-related deaths. Tumor metastasis is very complex and this process requires a tumor cell to acquire enhanced motility, invasiveness and anoikis resistance to successfully establish a tumor at a distal site. Metastatic potential of tumor cells is directly correlated with the expression levels of several angiogenic cytokines. Copper is a mandatory cofactor for the function of many of these angiogenic mediators as well as other proteins that play an important role in tumor cell motility and invasiveness. We have previously shown that tetrathiomolybdate (TM) is a potent chelator of copper and it mediates its anti-tumor effects by suppressing tumor angiogenesis. However, very little is known about the effect of TM on tumor cell function and tumor metastasis. In this study, we explored the mechanisms underlying TM-mediated inhibition of tumor metastasis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
India | 1 | 2% |
United States | 1 | 2% |
Australia | 1 | 2% |
Unknown | 40 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 27% |
Student > Ph. D. Student | 11 | 25% |
Professor | 4 | 9% |
Other | 3 | 7% |
Student > Master | 3 | 7% |
Other | 4 | 9% |
Unknown | 7 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 32% |
Biochemistry, Genetics and Molecular Biology | 9 | 20% |
Medicine and Dentistry | 8 | 18% |
Chemistry | 3 | 7% |
Engineering | 2 | 5% |
Other | 1 | 2% |
Unknown | 7 | 16% |