Title |
Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs
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Published in |
BMC Genomics, April 2011
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DOI | 10.1186/1471-2164-12-204 |
Pubmed ID | |
Authors |
Qianwei Wang, Jacqueline Chow, Jenny Hong, Anne Ferguson Smith, Carol Moreno, Peter Seaby, Paul Vrana, Kamelia Miri, Joon Tak, Eu Ddeum Chung, Gabriela Mastromonaco, Isabella Caniggia, Susannah Varmuza |
Abstract |
The proximal region of murine Chr 2 has long been known to harbour one or more imprinted genes from classic genetic studies involving reciprocal translocations. No imprinted gene had been identified from this region until our study demonstrated that the PcG gene Sfmbt2 is expressed from the paternally inherited allele in early embryos and extraembryonic tissues. Imprinted genes generally reside in clusters near elements termed Imprinting Control Regions (ICRs), suggesting that Sfmbt2 might represent an anchor for a new imprinted domain. |
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