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Molecular characterization of methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization and infection isolates in a Veterans Affairs hospital

Overview of attention for article published in Antimicrobial Resistance and Infection Control, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)

Mentioned by

blogs
1 blog
twitter
16 tweeters
facebook
2 Facebook pages

Citations

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14 Dimensions

Readers on

mendeley
45 Mendeley
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Title
Molecular characterization of methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization and infection isolates in a Veterans Affairs hospital
Published in
Antimicrobial Resistance and Infection Control, April 2015
DOI 10.1186/s13756-015-0048-5
Pubmed ID
Authors

Kalyani E Eko, Brett M Forshey, Margaret Carrel, Marin L Schweizer, Eli N Perencevich, Tara C Smith

Abstract

Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) is associated with increased infection risk, yet colonization and infection isolates are rarely compared within the same study. The objectives of this study were to compare colonization and infection isolates from a Veterans Administration hospital in Iowa, and to determine the prevalence of livestock-associated MRSA (LA-MRSA) colonization and infection in a state with high livestock density. All patients with available MRSA isolates collected through routine nasal screening (73%; n = 397) and from infections (27%; n = 148) between December 2010 and August 2012 were included and tested for spa type and presence of PVL and mecA genes. Clinical isolates were tested for antibiotic resistance patterns. Paired colonization and infection isolates were compared for genetic and phenotypic congruity. The most common spa types were t002 (and other CC5-associated strains; 65%) and t008 (and other CC8-associated strains; 20%). No classic LA-MRSA spa types were identified. CC5-associated strains were less likely to be associated with infections (22%; 77/353) compared with CC8-associated strains (49%; 53/109). MRSA colonization was more common among patients with infections (71%) compared with the general screening population (7%). In most cases (82%; 28/34), paired colonization and infection isolates were genetically and phenotypically indistinguishable. Our data demonstrate a direct link between antecedent nasal colonization and subsequent MRSA infection. Further, our data indicate variability in colonization and infection efficiency among MRSA genotypes, which points to the need to define the molecular determinants underlying emergence of S. aureus strains in the community and nosocomial setting.

Twitter Demographics

The data shown below were collected from the profiles of 16 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 20%
Researcher 8 18%
Student > Bachelor 6 13%
Professor 5 11%
Lecturer > Senior Lecturer 3 7%
Other 9 20%
Unknown 5 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 24%
Immunology and Microbiology 9 20%
Medicine and Dentistry 5 11%
Veterinary Science and Veterinary Medicine 4 9%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 8 18%
Unknown 6 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2015.
All research outputs
#1,526,073
of 19,208,681 outputs
Outputs from Antimicrobial Resistance and Infection Control
#205
of 1,097 outputs
Outputs of similar age
#23,380
of 235,713 outputs
Outputs of similar age from Antimicrobial Resistance and Infection Control
#1
of 1 outputs
Altmetric has tracked 19,208,681 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,097 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.0. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,713 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them