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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms
|
|---|---|
| Published in |
Diabetology & Metabolic Syndrome, March 2015
|
| DOI | 10.1186/s13098-015-0018-3 |
| Pubmed ID | |
| Authors |
Anne Briançon-Marjollet, Martin Weiszenstein, Marion Henri, Amandine Thomas, Diane Godin-Ribuot, Jan Polak |
| Abstract |
Modern lifestyle has profoundly modified human sleep habits. Sleep duration has shortened over recent decades from 8 to 6.5 hours resulting in chronic sleep deprivation. Additionally, irregular sleep, shift work and travelling across time zones lead to disruption of circadian rhythms and asynchrony between the master hypothalamic clock and pacemakers in peripheral tissues. Furthermore, obstructive sleep apnea syndrome (OSA), which affects 4 - 15% of the population, is not only characterized by impaired sleep architecture but also by repetitive hemoglobin desaturations during sleep. Epidemiological studies have identified impaired sleep as an independent risk factor for all cause of-, as well as for cardiovascular, mortality/morbidity. More recently, sleep abnormalities were causally linked to impairments in glucose homeostasis, metabolic syndrome and Type 2 Diabetes Mellitus (T2DM). This review summarized current knowledge on the metabolic alterations associated with the most prevalent sleep disturbances, i.e. short sleep duration, shift work and OSA. We have focused on various endocrine and molecular mechanisms underlying the associations between inadequate sleep quality, quantity and timing with impaired glucose tolerance, insulin resistance and pancreatic β-cell dysfunction. Of these mechanisms, the role of the hypothalamic-pituitary-adrenal axis, circadian pacemakers in peripheral tissues, adipose tissue metabolism, sympathetic nervous system activation, oxidative stress and whole-body inflammation are discussed. Additionally, the impact of intermittent hypoxia and sleep fragmentation (key components of OSA) on intracellular signaling and metabolism in muscle, liver, fat and pancreas are also examined. In summary, this review provides endocrine and molecular explanations for the associations between common sleep disturbances and the pathogenesis of T2DM. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 24% |
| United States | 3 | 18% |
| Saint Lucia | 1 | 6% |
| Australia | 1 | 6% |
| India | 1 | 6% |
| Unknown | 7 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 76% |
| Scientists | 2 | 12% |
| Practitioners (doctors, other healthcare professionals) | 2 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 430 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | <1% |
| Ireland | 1 | <1% |
| Brazil | 1 | <1% |
| Sweden | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 423 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 83 | 19% |
| Student > Master | 57 | 13% |
| Student > Ph. D. Student | 46 | 11% |
| Student > Postgraduate | 27 | 6% |
| Researcher | 24 | 6% |
| Other | 75 | 17% |
| Unknown | 118 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 118 | 27% |
| Agricultural and Biological Sciences | 40 | 9% |
| Nursing and Health Professions | 32 | 7% |
| Biochemistry, Genetics and Molecular Biology | 19 | 4% |
| Sports and Recreations | 17 | 4% |
| Other | 72 | 17% |
| Unknown | 132 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 464. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2023.
All research outputs
#59,988
of 25,793,330 outputs
Outputs from Diabetology & Metabolic Syndrome
#2
of 818 outputs
Outputs of similar age
#565
of 279,268 outputs
Outputs of similar age from Diabetology & Metabolic Syndrome
#1
of 23 outputs
Altmetric has tracked 25,793,330 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 818 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,268 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.