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Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster

Overview of attention for article published in BMC Genomics, September 2011
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Title
Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster
Published in
BMC Genomics, September 2011
DOI 10.1186/1471-2164-12-475
Pubmed ID
Authors

Sarah E Gonsalves, Scott J Neal, Amy S Kehoe, J Timothy Westwood

Abstract

The 20-hydroxyecdysone (20E) hierarchy of gene activation serves as an attractive model system for studying the mode of steroid hormone regulated gene expression and development. Many structural analogs of 20E exist in nature and among them the plant-derived ponasterone A (PoA) is the most potent. PoA has a higher affinity for the 20E nuclear receptor, composed of the ecysone receptor (EcR) and Ultraspiracle proteins, than 20E and a comparison of the genes regulated by these hormones has not been performed. Furthermore, in Drosophila different cell types elicit different morphological responses to 20E yet the cell type specificity of the 20E transcriptional response has not been examined on a genome-wide scale. We aim to characterize the transcriptional response to 20E and PoA in Drosophila Kc cells and to 20E in salivary glands and provide a robust comparison of genes involved in each response.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 36%
Student > Bachelor 8 18%
Student > Doctoral Student 4 9%
Researcher 4 9%
Student > Master 3 7%
Other 5 11%
Unknown 5 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 60%
Biochemistry, Genetics and Molecular Biology 10 22%
Environmental Science 1 2%
Medicine and Dentistry 1 2%
Neuroscience 1 2%
Other 0 0%
Unknown 5 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2011.
All research outputs
#18,297,449
of 22,653,392 outputs
Outputs from BMC Genomics
#8,137
of 10,607 outputs
Outputs of similar age
#109,585
of 131,769 outputs
Outputs of similar age from BMC Genomics
#74
of 90 outputs
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