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Synaptic dysfunction and septin protein family members in neurodegenerative diseases

Overview of attention for article published in Molecular Neurodegeneration, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)

Mentioned by

news
1 news outlet
twitter
3 tweeters
facebook
1 Facebook page

Citations

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79 Dimensions

Readers on

mendeley
158 Mendeley
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Title
Synaptic dysfunction and septin protein family members in neurodegenerative diseases
Published in
Molecular Neurodegeneration, April 2015
DOI 10.1186/s13024-015-0013-z
Pubmed ID
Authors

Mikael Marttinen, Kaisa MA Kurkinen, Hilkka Soininen, Annakaisa Haapasalo, Mikko Hiltunen

Abstract

Cognitive decline and disease progression in different neurodegenerative diseases typically involves synaptic dysfunction preceding the neuronal loss. The synaptic dysfunction is suggested to be caused by imbalanced synaptic plasticity i.e. enhanced induction of long-term depression and concomitantly decreased long-term potentiation accompanied with excess stimulation of extrasynaptic N-Methyl-D-aspartate (NMDA) receptors due to various disturbances in pre- and postsynaptic sites. Recent research has identified neurodegenerative disease-related changes in protein accumulation and aggregation, gene expression, and protein functions, which may contribute to imbalanced synaptic function. Nevertheless, a comprehensive understanding of the mechanisms regulating synaptic plasticity in health and disease is still lacking and therefore characterization of new candidates involved in these mechanisms is needed. Septins, a highly conserved group of guanosine-5'-triphosphate (GTP)-binding proteins, show high neuronal expression and are implicated in the regulation of synaptic vesicle trafficking and neurotransmitter release. In this review, we first summarize the evidence how synaptic dysfunction is related to the pathogenesis of Alzheimer's, Parkinson's and Huntington's disease and frontotemporal lobar degeneration. Then, we discuss different aspects of the potential involvement of the septin family members in the regulation of synaptic function in relation to the pathogenesis of neurodegenerative diseases.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 155 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 22%
Researcher 32 20%
Student > Master 18 11%
Student > Bachelor 18 11%
Student > Doctoral Student 10 6%
Other 21 13%
Unknown 24 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 21%
Neuroscience 30 19%
Biochemistry, Genetics and Molecular Biology 27 17%
Medicine and Dentistry 11 7%
Psychology 8 5%
Other 23 15%
Unknown 26 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2015.
All research outputs
#2,225,472
of 19,208,681 outputs
Outputs from Molecular Neurodegeneration
#264
of 743 outputs
Outputs of similar age
#33,034
of 237,221 outputs
Outputs of similar age from Molecular Neurodegeneration
#1
of 1 outputs
Altmetric has tracked 19,208,681 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 743 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,221 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them